LFU:online

The students understand basic knowledge of Pharmacology.

• Overview of drug targets (receptors, DNA, enzymes), including drug action on GPCRs, biased signaling; agonist, antagonist, intrinsic activity, inverse agonist (example opioid receptors,  addiction, tolerance)
• enzyme action, quantitative aspects, Kd, Ki; selectivity/specificity;
• Pharmacology: drug action in other major signaling pathways (i.e. pathways with multiple drug actions. LDL-C: Statin, PCSK9, Colestyramin, Ezetimibe; pioglitazon; drug action in dopaminergic system); including clinical aspects.
• drug action in electrical excitable cells (i.e. ion channel modulators, 5-HT, Ach)
• selected pharmacological methods: GTP-gamma-S, cAMP, Beta-arrestin, radio-/fluorescent ligand binding, electrophysiology.
• self-centered learning content

Vorlesung (Computer-unterstützte visualisierte Präsentation, online Handouts)

schriftlich

Students must select 2 lectures offered (VO2 each)