LFU:online

Biochemistry, physiology and pathophysiology of key cellular signaling pathways

• overview: cell proliferation and hyper- and hypoproliferative diseases (including cancer) (Hengst)

• cytokines, hormones and hormone receptors: types, pathobiochemistry, signaling. assembly of signaling complexes; phosphorylation, tyrosine and sein/theronin kinases (Hengst)

• intracellular signaling; second messengers, MAPK ... (Hengst)

• regulation of cell proliferation and the cell cycle; transcription (E2Fs), phosphorylation and ubiquitination (Hengst)

• Signaling by the UPR: Principles, new therapeutic strategies for cancer, cardiovascular diseases, genetic disorders and neurodegeneration (Farhan)

• Therapeutic utilization of degradatrive cellular pathways (autophagy, Ubiquitin.signaling, proteasome) for cancer and neurodegenerative diseases (Farhan)

• Therapeutic utilization of post-translational modifications such as glycosylation and sulfation (Farhan)

• Inflammatory Response Pathways: Principles, associated diseases and therapeutic interventions. PRR signaling and its key signaling modules (NF-KB, JAK/STAT, MAPKs/Ap1, NLRP3/ inflammasome); genetic and signaling defects in selected inflammatory disorders (e.g. inflammatory bowel diseases and inflammation-associated cancer); current therapeutic strategies and approved drugs. (Valovka)

• Therapeutic targeting of key signaling regulators of inflammation: Structural basis and molecular mechanisms Protein-protein interactions; posttranslational modifications: ubiquitination, phosphorylation, acetylation, methylation; indirect mechanisms. (Valovka)

• Development of new anti-inflammatory drugs: screening, identification and validation. (Valovka)

Vorlesung (Computer-unterstützte visualisierte Präsentation, online Handouts)

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